Surgical stress and cancer progression: the twisted tango, Molecular Cancer

Surgical resection is an important avenue for cancer treatment, which, in most cases, can effectively alleviate the patient symptoms. However, accumulating evidence has documented that surgical resection potentially enhances metastatic seeding of tumor cells. In this review, we revisit the literature on surgical stress, and outline the mechanisms by which surgical stress, including ischemia/reperfusion injury, activation of sympathetic nervous system, inflammation, systemically hypercoagulable state, immune suppression and effects of anesthetic agents, promotes tumor metastasis. We also propose preventive strategies or resolution of tumor metastasis caused by surgical stress.

Tumor regionalization after surgery: Roles of the tumor microenvironment and neutrophil extracellular traps

Surgical stress response and cancer outcomes: a narrative review - O'Rourke - Digestive Medicine Research

PDF) Pre-metastatic niches, exosomes and circulating tumor cells. Early mechanisms of tumor dissemination and the relation to surgery

Interactions of occult tumor spread and surgical technique on overall and disease-free survival in patients operated for stage I and II right-sided colon cancer

Surgical Stress and Cancer Progression: New Findings and Future Perspectives

Surgical stress response and promotion of metastasis in colorectal cancer: a complex and heterogeneous process

Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer

Immune-based therapies in penile cancer

Stresses in the metastatic cascade: molecular mechanisms and therapeutic opportunities. - Abstract - Europe PMC

Cancer Stem Cells are Actually Stem Cells with Disordered Differentiation: the Monophyletic Origin of Cancer

Molecular mechanisms underlying the regulation of tumour suppressor genes in lung cancer - ScienceDirect

New insights into the correlations between circulating tumor cells and target organ metastasis

Surgical stress response and promotion of metastasis in colorectal cancer: a complex and heterogeneous process

Full article: Surgical Trauma-induced CCL2 Upregulation Mediates Lung Cancer Progression by Promoting Treg Recruitment in Mice and Patients

Micellar nanoparticles inhibit the postoperative inflammation, recurrence and pulmonary metastasis of 4T1 breast cancer by blocking NF-κB pathway and promoting MDSCs depletion - ScienceDirect