Guillain-Barré and Alpha-gal Syndromes: Saccharides-induced Immune Responses

The molecular interactions between hosts, vectors and pathogens drive the etiology of infectious diseases. At first sight, the Guillain-Barré and Alpha-Gal syndromes have quite different etiologies but, as proposed here, a closer look into the immune response to galactose-containing oligosaccharide structures that characterizes these two diseases reveals striking commonalities. In this Opinion paper, we address the main molecular drivers of two apparently unrelated diseases, and how the characterization of the immune response and immunological tolerance would advance the control and prevention of these diseases.

Jose DE LA FUENTE, Professor (Full), PhD, University of Castilla-La Mancha, Ciudad Real, Sanidad y Biotecnología (SaBio)

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Iván PACHECO, PhD Student, University of Castilla-La Mancha, Ciudad Real, Sanidad y Biotecnología (SaBio)

Quantitative proteomics reveals Piccolo as a candidate serological correlate of recovery from Guillain-Barré syndrome

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Quantitative proteomics reveals Piccolo as a candidate serological correlate of recovery from Guillain-Barré syndrome

Diagnosis and treatment of the alpha-Gal syndrome

Marinela CONTRERAS, PhD Juan de La Cierva Incorporación, PhD, Spanish National Research Council, Madrid, CSIC, Instituto de Investigación en Recursos Cinegéticos