A protein with a dual role: Both repair and mutation

Using a specialized protein, all bacteria are capable of rapidly and effectively repairing damage to their DNA from UV. However, this mutation frequency decline (Mfd) protein plays another role and causes mutations. A team1 involving scientists from CNRS, ENS-PSL and supported by Inserm has demonstrated and described this phenomenon. Better understanding of mutations opens up prospects in the fight against resistance to antibiotics and anti-cancer therapies. This study was published in PNAS on 5 April 2021.

Chapter 12: DNA Damage and Repair - Chemistry

DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis - ScienceDirect

Press area

DNA Repair Protein - an overview

Elledge Lab

Newsroom

Dual Functions of a Rubisco Activase in Metabolic Repair and Recruitment to Carboxysomes - ScienceDirect

Press area

Nonsense Mutation - an overview

Newsroom

24.2: DNA Mutations, Damage, and Repair - Biology LibreTexts

Protein and Scientist - Clinical Research Informer